MITCHELL MEDAL LECTURE

The Sir David Cuthbertson Medal Lecture 1991

Oersted Medal Lecture 2002: Reforming the Mathematical Language of Physics

The connection between physics teaching and research at its deepest level can be illuminated by Physics Education Research (PER). For students and scientists alike, what they know and learn about physics is profoundly shaped by the conceptual tools at their command. Physicists employ a miscellaneous assortment of mathematical tools in ways that contribute to a fragmentation of knowledge. We can...

The Edward Teller Medal Lecture: High Intensity Lasers and the Road to Ignition

There has been much progress in the development of high intensity lasers and in the science of laser driven inertially confined fusion such that ignition is now a near term prospect. This lecture reviews the field with particular emphasis on areas of my own involvement.

Novartis Medal Lecture. Antibodies: a paradigm for the evolution of molecular recognition.

Novel proteins have been elaborated over evolutionary time by an iterative alternation of mutation and selection. In a similar way, the humoral immune system also uses an iterative alternation of mutation and selection to generate novel antibodies that display a high affinity for their cognate antigen -- but this is achieved in a matter of a days. Gene rearrangement is used to produce a primary...

Colworth Medal lecture. Detection, repair and signalling of DNA double-strand breaks.

Introduction The cells of our bodies are continually under assault by a wide array of DNA-damaging agents. These include reactive oxygen species generated as a consequence of oxidative metabolism, UV light, ionizing radiation and radio-mimetic chemicals. The forms of damage inflicted are many, and range from base adducts, interand intrastrand cross-links, DNA single-strand breaks and DNA double...